Why does Mira measure PdG rather than 5α and 5β-pregnanediol like DUTCH?Updated 33 minutes ago

Mira measures PdG because it is the best urinary marker for ovulation confirmation and luteal function assessment. 

The two most clinically actionable questions in cycle monitoring. PdG consistently demonstrates the highest correlation with serum progesterone of the three markers and has the most mature, well-validated clinical application for this purpose.
5α and 5β-pregnanediol, by contrast, are better suited for metabolic pathway analysis — understanding how progesterone is being broken down — rather than confirming whether ovulation occurred or whether luteal function is adequate.

Mira is not designed to assess estrogen or progesterone metabolism pathways. PdG reflects the presence and pattern of progesterone production, not how it is being broken down. For patients where metabolic pathway analysis is clinically indicated — such as those with PMDD, detoxification concerns, or complex hormonal presentations — DUTCH or similar comprehensive testing remains the appropriate tool. Mira can, however, help optimally time that testing by confirming cycle phase.

Mira's primary clinical value is longitudinal, real-time cycle monitoring — confirming ovulation, assessing luteal function, and identifying cycle patterns over time. PdG is the gold standard urinary marker for exactly these applications. For providers requiring deeper metabolic or neurosteroid pathway analysis, complementary testing such as DUTCH remains a valuable adjunct.